At least three people were killed in a fiery pileup on an interstate outside Phoenix early Thursday involving two semi-trucks and two other vehicles, officials said.

The crash sparked an “extensive hazardous materials fire,” Arizona Department of Public Safety spokesperson Bart Graves told The Post, while warning the death toll may increase.

The deadly chain of events appeared to be sparked by a semi-truck that crashed on Interstate 10 near the Loop 202 Santan Freeway interchange in Chandler, Arizona around 6:10 a.m., according to AZ Family.

Aerial footage from ABC 15 Arizona showed investigators circling the smoldering remains of an obliterated truck branded with the logo of Logiflex.

Multiple other vehicles were also involved in the fatal accident, according to the outlet. It was not immediately clear what had caused the deadly wreckage. 

The accident came hours after multiple semi-trucks were involved in a crash on the same interstate five miles away, according to the outlet.

Two semis were stopped on I-10 for a vehicle fire when another one barrelled into them around 3:30 a.m., officials confirmed to The Post.

“Inattention” appeared to be the catalyst for the deadly wreckage, Graves said.