For the first time ever, Americans are more likely to die from an opioid overdose than in a car crash, according to new statistics released on Monday.

The odds of dying from accidentally overdosing on drugs is 1 in 96 — compared to perishing in a motor vehicle crash, which carries a 1 in 103 chance, the National Safety Council study found.

In 2017, drug overdoses were to blame in more than 65,000 deaths — a number that’s skyrocketed 633 percent since 1999.

The hardest hit age group was 25 to 34, which saw 12,325 OD deaths. More than two-thirds of that total were men.

The drug death toll is on an upward trajectory — the 2017 total is a 15 percent increase from the year before and a 904 percent increase from 1999.

“We’ve made significant strides in overall longevity in the United States, but we are dying from things typically called accidents at rates we haven’t seen in half a century,” Ken Kolosh, manager of statistics at the National Safety Council, said in a statement. “We cannot be complacent about 466 lives lost every day. This new analysis reinforces that we must consistently prioritize safety at work, at home and on the road to prevent these dire outcomes.”

Even Americans who are drug-free still face a 1 in 25 shot of losing their lives in a preventable, accidental way, which, remarkably, was the third leading cause of death last year behind the No. 1 killer heart disease and cancer, the runner-up.

Falls are the No. 3 top cause of preventable death and a nasty tumble is more likely to kill someone than ever before. Those lifetime odds are 1 in 114 — an uptick from 1 in 119 just a year ago.

To reach its findings, the nonprofit NSC examined data for unintentional, preventable injuries — commonly known as “accidents.” It found 169,936 people died in accidents last year.

Another 47.2 million, or about 1 in 7, suffered injuries that could’ve been prevented.

NSC also calculated intentional deaths, which is divided into four subgroups — intentional self-harm or suicide, assault or homicide, legal intervention and operations of war.

The Illinois-based group found 47,173 people committed suicide last year. Assault deaths totaled 19,510. There were 616 deaths by legal intervention, such as legal execution, and operations of war, which does not include overseas deaths, claimed five lives.

Piquing morbid curiosity, NSC included statistics on one of the most common phobias — airplane crashes.

“Commercial scheduled air travel is among the safest modes of transportation; the lifetime odds of dying as an aircraft passenger is 1 in 205,552,” the group found.

Crashes involving US-registered civilian aircraft slightly decreased from 2016 to 2017 — from 1,335 to 1,316, according to preliminary information.