The NYPD pepper-sprayed and arrested unruly protesters among 700 activists who marched on Fifth Avenue and dangled from Central Park statues during an anti-Trump rally Saturday.

Cops shut down several blocks of Fifth Avenue as activists marched from Columbus Circle to the Trump International Hotel & Tower.

Protesters were pepper-sprayed when they tried to breach police barricades keeping them to the sidewalks at Sixth Avenue and 59th Street. Several got into shoving matches with officers. Others broke into anti-cop chants. At least three were arrested for ­disorderly conduct.

Three were charged with disorderly conduct, a violation.

The demonstrators — opposed by about a dozen Trump supporters — had massed near the Trump International at noon. They were kept in check there by a huge NYPD presence.

One pro-Trump demonstrator said he was treated like “absolute garbage” by the anti-Trump crowd. Jim MacDonald of Flushing, Queens, said one young woman screaming “F–k Trump! F–k fascism!” spit on him.

“The other side is like a dangerous mob,” he said. “We will exercise our right to free speech whether the mob likes it or not.”

The crowd chanted slogans like “Racist sexist anti-gay, Donald Trump go away” and “Only difference is the name! Hitler, Trump is the same!” for an hour as its numbers swelled. Activists carried homemade signs that hammered Trump’s stance on border control (“Build a Wall Around Trump and Make Him Pay For It”), women (“Women to Trump: It’s Mutual”) and the size of his body parts (“Put America in Bigger Hands”).

“We’re disgusted with his rhetoric,” said protester Giovanni Garcia, 48, who emigrated from Mexico as a child. “I don’t want him to get any farther.”
Peter Blewett, 20, agreed: “We’re fighting for the soul of our country,” he said.

Organizers, led by Cosmopolitan Antifascists and joined by Millions March NYC, the Black Lives Matter group NYC Shut It Down, and others, lost control as the crowd began to move along 59th Street toward Trump’s namesake skyscraper.

With Fifth Avenue blocked, the protesters circled the area around Trump Tower and marched back uptown. Dozens, including two beating bass drums, climbed up the Maine Monument at the southwest corner of Central Park.

Meanwhile, in Arizona, a band of 50 protesters stopped highway traffic for two hours Saturday in an attempt to shut down a planned Trump rally. A crowd of 20,000 made it to the site in Fountain Hills, where Trump was stumping ahead of Tuesday’s Republican primary.

Some demonstrators chained themselves to their cars, which they parked on the highway.

Sheriff’s deputies called for tow trucks to remove the vehicles.