President Trump ripped Republican Sens. Lisa Murkowski and Thom Tillis as “losers” Wednesday after they called on Homeland Security Secretary Kristi Noem to resign following the Jan. 24 killing of Alex Pretti by border agents.

“Well, they’re both losers. You know, what can I tell you? They’re terrible senators. One is gone and the other should be gone,” Trump told ABC News.

“In the meantime, I have a border that’s perfect — the strongest, one of the strongest borders anywhere in the world. We went from the weakest border in the world to one of the strongest borders in the world.”

Murkowski, 68, and Tillis, 65, became the first GOP members of Congress to demand the cabinet secretary step down after both voted to confirm her on Jan. 25 last year.

“I think that what she’s done in Minnesota should be disqualifying,” Tillis (R-NC) told reporters on Capitol Hill. “She should be out of a job. I mean, really, it’s just amateurish. It’s making the president look bad on policies that he won on.

“He won on a strong message on immigration,” the North Carolinian went on. “And now nobody’s talking about that. They’re not talking about securing the border. They’re talking about the incompetence of the leader of homeland security.”

Murkowski (R-Alaska) initially said that it was “probably time for [Noem] to step down” before taking a firmer position in telling NBC News: “Yes, she should go.”

Tillis has announced he will not seek re-election to a third Senate term this year, while Murkowski is not due to run again until 2028.

“What Murkowski says — she’s always against the Republicans anyway,” Trump told ABC News. “And Tillis decided to drop out. So, you know, he lost his voice once he did that.”

Trump has also rejected demands by congressional Democrats that Noem be fired over her response to the shooting of Pretti, an ICU nurse who was protesting immigration enforcement operations in Minneapolis.

“I think she’s doing a very good job. The border is totally secure,” the president told reporters of Noem Tuesday, rejecting the suggestion that his dispatching border czar Tom Homan to Minnesota to handle the fallout from the Pretti shooting amounted to sidelining the secretary.

“I do that all the time. I shake up teams,” Trump said. “I don’t think it’s a pullback, it’s a little bit of a change.”

As Homan headed to the frozen north Monday night, Noem, the former South Dakota governor, and her top adviser Corey Lewandowski met with Trump for nearly two hours in the Oval Office.

When asked Tuesday if Noem would step down, the president gave a one-word answer: “No.”