Top Republicans are lining up to demand that President Biden must leave the Oval Office immediately after his announcement that he’s dropping out of the 2024 presidential race.

Republican vice presidential nominee JD Vance is leading the wave — which was joined by House Speaker Mike Johnson and others.

Hours before Biden’s announcement, the Ohio senator said that if the president isn’t fit to campaign, he cannot be trusted to remain in the White House.

“Not running for reelection would be a clear admission that President Trump was right all along about Biden not being mentally fit enough to serve as Commander-in-Chief,” Vance wrote on X.

“There is no middle ground,” he continued.

Biden sent shockwaves through the political universe Sunday afternoon, caving to massive pressure to quit his campaign.

House Speaker Mike Johnson (R-La.) also immediately called on Biden to resign.

“If Joe Biden is not fit to run for President, he is not fit to serve as President. He must resign the office immediately. November 5 cannot arrive soon enough,” Johnson said.

Rep. Elise Stefanik (R-NY), the No. 3 Republican in the House, also piled on.

“The Democrat Party is in absolute free fall for their blatantly corrupt and desperate attempt to cover up the fact that Joe Biden is unfit for office,” Stefanik posted to X.

“Then RESIGN your office. If you can’t run a mere political campaign, you can’t be President,” Sen. Josh Hawley (R-Mo) added.

“Being President is the hardest job in the world, and I no longer have confidence that Joe Biden can effectively execute his duties as Commander-in-Chief,” Sen. Steve Daines (R-Mont.) wrote.

“Democrats can’t have it both ways. If Joe Biden can’t handle a debate or a rally, he can’t stand up to Putin or have access to the nuclear codes,” Savannah Viar, deputy communications director for the National Republican Congressional Committee, also wrote in a statement Sunday afternoon.

Biden quitting marks the end of weeks of building pressure from fellow Democrats pushing the octogenarian president to hand the keys to another person.

What to know about President Biden's decision to drop out of the 2024 presidential race:

• President Biden announced Sunday he is dropping out of the 2024 presidential race — after weeks of prominent Democrats and donors calling on him to withdraw following his disastrous performance in the first presidential debate.
• In a letter posted on X Sunday afternoon, Biden admitted that it is in the “best interest of my party and country” for him to step down as the Democratic nominee.
• Biden wrote that he intends to serve out the remainder of his term and will address the country on his decision later this week.
• In a follow-up X post, Biden endorsed Vice President Kamala Harris for the suddenly open Democratic nomination. “Today I want to offer my full support and endorsement for Kamala to be the nominee of our party this year,” the president wrote.
• Former President Donald Trump reacted to the news by labeling Biden the “worst president in the history of our country” in a call with CNN.

Earlier Sunday, Sen. Joe Manchin (I-WV) had joined four of his Senate Democratic colleagues in calling on Biden to step aside and allow “a new generation” to come forward.

Manchin, who left the Democratic Party in May but still caucuses with them, joins the likes of Sens. Peter Welch of Vermont, Jon Tester of Montana, Martin Heinrich of New Mexico and Sherrod Brown of Ohio in the call.

Even one of Biden’s most longstanding and visible supporters, Hollywood star George Clooney, called on him to drop out of the race in an op-ed published on July 10.

Upon quitting, Biden immediately endorsed Vice President Kamala Harris to take his spot atop the ticket.