The Senate blocked a bill that would have funded most of the government through the end of September on the eve of their deadline to avoid a partial shutdown.

Just 45 senators, all Republicans, voted to advance House-passed bills funding the Pentagon and Departments of Labor, Health and Human Services, Education, Transportation and Housing and Urban Development.

Republicans Ted Budd of North Carolina, Ron Johnson of Wisconsin, Mike Lee of Utah, Rand Paul of Kentucky, Ashley Moody and Rick Scott of Florida, Majority Leader John Thune of South Dakota, and Tommy Tuberville of Alabama voted against advancing the bill.

Thune voted “no” to satisfy a procedural requirement that would allow him to bring the bill again.

Democrats had vowed to block the bills without Republicans committing to reforming Immigration and Customs Enforcement (ICE) and Customs and Border Protection (CBP) practices.

That move came after the fatal shooting of Alex Pretti, 37, by a Border Patrol agent — the second anti-ICE agitator killed by a federal officer in Minneapolis since the start of President Trump’s “Operation Metro Surge.”

Some senators are still seeking a compromise package of five funding bills that will strip out Department of Homeland Security appropriations, though Thune hadn’t publicly indicated support for that option before Thursday’s vote.

The six bills passed the House in a series of bipartisan votes last week, with at least seven Democrats backing DHS funding — before reversing course in the wake of the Pretti shooting.

Senate Minority Leader Chuck Schumer (D-NY) has said a new DHS bill should include new provisions forcing ICE agents to conduct removal operations with “masks off, body cameras on.”

The bill must also beef up rules for the use of warrants, create a unilateral code of conduct for federal agents and “end roving patrols” for deportees.

Trump administration officials have noted that if local and state law enforcement entities cooperated with ICE, there would be no need for the patrols.

If DHS funding is pulled out of the broader package, the House would have to reconvene to pass the revised measure, meaning a partial shutdown would occur between Saturday and Monday.

“We’ll get everybody back as soon as we can,” House Speaker Mike Johnson (R-La.) told reporters Thursday. “The weather may be an issue. There are some members on codels [codelegation trips] across the world, literally, so we’ll do the best we can.”

The five bills that have yet to pass the Senate include money for the Departments of Defense, State, Education and the Treasury.

DHS could then be separately funded at current levels through an additional bill in both chambers of Congress while negotiations continue over the funding cuts.

The other six of 12 major bills providing all funding for the federal government have already passed.

“Hopefully, we won’t have a shutdown,” Trump said during a Cabinet meeting on Thursday ahead of the failed Senate vote.

“The Democrats, I believe, don’t want to see it either,” the president noted. “So we’ll work in a very bipartisan way I believe not to have a shutdown. We don’t want a shutdown.”

Senate Democrats forced the longest shutdown in US history last year while seeking to add expanded health care subsidies to a government funding bill.

After 43 days, a handful of senators in their caucus crossed party lines to reopen the government — though several of those same Democrats have since expressed support for tinkering with DHS’ funding.

Sen. John Fetterman (D-Pa.), one of those members, said Monday that he “reject[s] calls to defund or abolish ICE” but opposes funding DHS’ “ungovernable and dangerous” operations — especially in Minneapolis.