WASHINGTON — President Trump’s budget office is instructing the Department of Transportation and Centers for Disease Control and Prevention to claw back more than $1.5 billion from blue states on grounds the money was being mishandled, officials told The Post.

The Office of Management and Budget (OMB) told the DOT Wednesday to cancel more than $943 million, while the CDC was ordered to nix at least $602 million meant for California, Colorado, Illinois and Minnesota.

An OMB spokesperson said that the states were being targeted for “waste and mismanagement” of taxpayer funds.

Illinois was slated to receive the largest of the transportation-related grants, with $100 million provided to the state’s Environmental Protection Agency to build electric vehicle (EV) charging stations. A DOT spokesman confirmed the cuts were being carried out.

“Time and time again, the Trump Administration has attempted to politicize and punish certain states President Trump does not like,” a spokesperson for Illinois Gov. JB Pritzker’s office said in a statement. “It’s wrong and often illegal, so Illinois will always fight for the resources and services our taxpayers are owed.”

The health care money, some of which was passed under former President Joe Biden, funded research on Diversity, Equity and Inclusion (DEI) initiatives or transgender medicine that was “not in line with administration policy,” according to White House officials.

The OMB spokesperson added that more grant cancellations were expected. HHS reps didn’t immediately confirm the cuts.

Trump had warned so-called “sanctuary cities or states” that he would begin halting the funding in February, saying their policies foment “fraud and crime and all of the other problems that come.”

If the Trump administration is successful in clawing back the money, Minnesota would lose $15 million in federal funding for EV chargers in poor neighborhoods and “environmental justice communities” would also be scratched out.

Additionally, the feds would pull $4.9 million from Colorado’s Boulder County meant for EV chargers “in low and moderate-income neighborhoods,” and Illinois would have to forgo $3.6 million for a research study aimed at translating the Commercial Driver’s License (CDL) test into Spanish.

“At this time, Colorado has not received any official cancellation notices from the federal administration related to these grants,” a rep for Gov. Jared Polis said in a statement. “There is nothing ‘woke’ about making sure American roads are safer for everyone.”

Transportation Secretary Sean Duffy has already threatened to hold up tens of millions in other federal funding over lax rules surrounding CDLs for foreign drivers in New York.

The DOT cuts in California included $15 million for “robust, accessible, and equitable” EV charging network for “disadvantaged communities” in nine counties around San Francisco.

Another $2 million was set aside for the Golden State’s “climate change adaptation” plans.

None of the CDC grants being yanked were for disease-specific research, the officials said.

Chicago was in line to receive $7 million for research involving “adolescents, racial and ethnic minorities and men who have sex with men” being “disproportionately affected with Sexually Transmitted Diseases (STDs).”

Another $7.2 million was put on the chopping block for the state branch of the American Medical Association, which officials said had supported gender reassignment surgery for children.

At least $3 million was outlined for Colorado to “Address COVID-19 Health Disparities Among Populations at High-Risk and Underserved, Including Racial and Ethnic Minority Populations and Rural Communities” — and another $1.2 million for the state to “partner with local public health departments, local health agencies, community-based organizations, STD clinics, family planning clinics, Title X clinics.”

Los Angeles County was to be stripped of $1.1 million in remaining funding for an HIV behavioral survey after an initial $4.3 million grant was approved in January 2022.

California universities also were awaiting hundreds of thousands of federal dollars for research on “reducing social isolation among older LGBTQ adults,” “Creating Medical Trust with Latinx Communities” and a National Transgender Health Summit.

The City of San Francisco also had $337,000 remaining from a larger grant to be paid out for “intersectoral climate adaptation.”

“Once again Trump is treating the White House like one of his bad reality shows. We’ve seen this clown show before, and we know how it ends — with Trump losing,” a spokesperson for Gov. Gavin Newsom said. “These cuts are purely political and mirror his recent losing actions rejected by the court. We will continue fighting for Californians.”

Minneapolis would also have gotten around $754,000 for “Racial and Ethnic Approaches to Community Health” ahead of Wednesday’s announcement.

In January, the Department of Health and Human Services, which oversees the CDC, moved to cut $10 billion for the four blue states and New York, The Post first reported. A judge put that order on pause days later.

Democrats like Empire State Gov. Kathy Hochul had accused the White House of politicizing federal funding for child care and other social services

“I believe that we’ll be successful in court,” Hochul told reporters last month. “We’ll fight this with every fiber of our being, because our kids should not be political pawns in a fight that Donald Trump seems to have with blue state governors.”

Polis’ spokesperson added: “We will continue to fight back against unlawful grant terminations by the federal administration, as we have done with repeated success over the past year. For every dollar Colorado contributes to the federal government, we only get 90 cents in return, so any attempt to strip away funding to our state is absurd.”

Reps for Minnesota Gov. Tim Walz did not respond to a request for comment Wednesday.