Israel's Defence Minister Israel Katz warned Iran's Supreme Leader Ayatollah Ali Khamenei that "Tehran will burn" if it keeps firing missiles at Israeli civilians.

"The Iranian dictator is taking the citizens of Iran hostage, bringing about a reality in which they, and especially Teheran's residents, will pay a heavy price for the flagrant harm inflicted upon Israel's citizens. If Khamenei continues to fire missiles at the Israeli home front, Tehran will burn," Katz said in a statement.

Iran said the dialogue with the US over Tehran’s nuclear program is “meaningless” after Israel’s biggest-ever military strike against its longstanding enemy, but said it is yet to decide on whether to attend planned talks on Sunday.

“The other side (the US) acted in a way that makes dialog meaningless. You cannot claim to negotiate and at the same time divide work by allowing the Zionist regime (Israel) to target Iran’s territory,” state media on Saturday quoted foreign ministry spokesperson Esmaeil Baghaei as saying.

“It is still unclear what decision we will make on Sunday in this regard,” Baghaei was quoted as saying.

He said Israel “succeeded in influencing” the diplomatic process and the Israeli attack would not have happened without Washington’s permission, accusing Washington of supporting the attack.

Iran earlier accused the US of being complicit in Israel’s attacks, but Washington denied the allegation and told Tehran at the United Nations Security Council that it would be “wise” to negotiate over its nuclear program.

The sixth round of US-Iran nuclear talks was set to be held on Sunday in Muscat, but it was unclear whether it would go ahead after the Israeli strikes.

Iran denies that its uranium enrichment program is for anything other than civilian purposes, rejecting Israeli allegations that it is secretly developing nuclear weapons.

US President Donald Trump told Reuters that he and his team had known the Israeli attacks were coming but they still saw room for an accord.

Two Iranian senior generals were killed in Israeli strikes Saturday morning, according to the Times of Israel, citing Iranian state media.

Iran's deputy head of intelligence of the armed forces general staff, General Gholamreza Mehrabi and deputy head of operations, General Mehdi Rabbani died in attacks on Iran's nuclear and air defense systems, the outlet reported.

Nine senior nuclear scientists were also "eliminated," the IDF said.

At least 20 senior Iranian commanders were killed in Israel’s initial attack on Friday, including Revolutionary Guard leader Gen. Hossein Salami, and armed forces chief of staff Mohammad Bagheri.

Israel attacked Iran's defense system in an overnight strike on Tehran, the Jewish State's air force reported.

"Dozens of Air Force fighter jets attacked dozens of targets in Tehran overnight, including surface-to-air missile infrastructure," the IAF said on X.

Israel's Air Force's overnight attack was an attempt to dismantle Iran's air defense capabilities in the capital region.

The post included a video of the fighter jets preparing to take off from a base, heading to Iran.

Air Force Commander Maj. Gen. Tomer Bar celebrated the strikes as a successful attack against Iran.

"After a powerful day in which we attacked hundreds of targets, including dozens of anti-aircraft targets, we carried out a wave of precise strikes of operational and national significance over the skies of Tehran, which improves our air superiority and freedom of action in Iran," Bar said.

Israel's initial attacks on Iran's air defense systems allowed the air force to fly manned aircraft over it's enemies capital without fear of being shot down.

For the first time since the beginning of the war, dozens of Air Force fighter jets flew over the skies of Tehran, more than 1,500 kilometers from the territory of the State of Israel, and attacked defense positions in the Tehran area," Bar added. "We chose to act in the face of an existential threat to the security of our citizens, with professionalism, determination and precision."

Bar warned the air force would continue its attacks on Iran as part of Israel's ongoing operation against the Islamic Regime.

US Ambassador to Israel Mike Huckabee said he was moved to a shelter in Jerusalem five times during Iran's counterattack.

"Been rough nite in Israel. Had to head to shelter 5 times during the nite," Huckabee wrote on X on Saturday morning

"It’s now Shabbat here. Should be quiet. Probably won’t be. Entire nation under orders to stay near shelter," he added.

Huckabee has been at the embassy in Jerusalem since Thursday when Israel launched Operation "Rising Lion" against Iran.

He has been "closely monitoring the situation."

The Israeli death toll rose to three as hospitals were flooded with dozens of wounded civilians after a wave of retaliatory missile strikes from Iran rained down on the Jewish state overnight Friday.

One woman succumbed to her injuries after being taken to Beilinson Hospital in Petah Tikva, increasing the death toll in Israel to three.

At least 43 people are being treated at Sheba Medical Center in Ramat Gan, while Shamir Medical Center in Be'er Ya'akov reported four wounded — two in moderate condition and two in mild — are currently receiving care, the Times of Israel reported.

Seven injured individuals were evacuated overnight to Ichilov Medical Center in Tel Aviv, with most in mild condition and one in moderate condition.

Two men — ages 88 and 57 — and a 64-year-old woman were also treated at Galilee Medical Center in Nahariyya after they were injured seeking shelter during the overnight barrages, the outlet reported.

Iran's UN ambassador said that Israel's massive airstrike on Iran killed 78 and injured more than 320 people, One American Now reported.

The surprise attack also took out at least 20 Iranian commanders, sources said, including the head of its Revolutionary Guard. Six nuclear scientists were also confirmed dead in the strikes.

Motorists discovered the smouldering remains of an Iranian missile sitting in the street in Israel.

Smoke rose from the white casing of a rocket after it was shot down by Israeli intercepting missiles, CNN's International Diplomatic Editor Nic Robertson reported on X.

"This just came down. We were watching intercepts in the sky above me and there was a lot of loud explosions and impacts, and you can see here this missile here, lying in the road is still smoking," he said.

Robertson reported the missile was part of the salvo Iranian launched at Israel early Saturday morning.

Conservative CNN pundit Scott Jennings is trapped in Israel after Iran launched a barrage of retaliatory missile attacks on the Jewish state Friday.

"There have been a few surprises that I didn't anticipate during my trip to Israel, to say the least," said Jennings, who has posted several videos on X of missile intercepts from his hotel on the Sea of Galilee.

"Don't think I am getting out of Israel today! But will continue to report on what I see and hear."

Jennings announced earlier this week he'd be off air as he traveled to Israel, where he met with Hamas hostages and visited areas hardest hit by the terror group's deadly Oct. 7, 2023, attack.

He has since been documenting Friday's wave of attacks on Israel, which launched a massive airstrike on Iran hours earlier to destroy nuclear facilities, missile factories and its military.

"President Trump told Iran they had 60 days to make a deal. They didn't listen," he wrote in a separate post.

"Now they're paying the price. What's incredible is that the US and Israel actively planned for this scenario of non-compliance. What they pulled off is miraculous."

United Nations Secretary-General Antonio Guterres is urging Israel and Iran to end their attacks as tensions continue to escalate between the two nations.

“Israeli bombardment of Iranian nuclear sites. Iranian missile strikes in Tel Aviv. Enough escalation. Time to stop. Peace and diplomacy must prevail,” he implored on X.