Israel intercepted a ballistic missile that Hezbollah fired deep into the heart of the Jewish state on Wednesday — a thus-far unprecedented escalation in the conflict with the Lebanese terror group. 

The Israel Defense Forces said Hezbollah fired approximately 40 missiles from Lebanon early Wednesday, with a Qadr 1 missile aimed at the Mossad’s headquarters in Tel Aviv, the first such attack in the conflict that began on Oct. 8. 

“According to the information I have at the moment, this is the first time in history that Hezbollah fired a rocket or missile toward the city of Tel Aviv,” IDF spokesman Lt. Col. Nadav Shoshani said in a statement. 

White House national security spokesperson John Kirby said the attack on Tel Aviv was “deeply concerning.”

“[It’s] evidence again… that Israel is facing a legitimate threat from a terrorist group backed by Iran,” Kirby said during a CNN interview Wednesday. 

“No nation should have to live with these threats right across their border, right next door,” he added.

While the ballistic missile fired at the intelligence agency was intercepted, another projectile was confirmed to hit an assisted-living facility in northern Israel. 

Other missiles were detected in the city of Netanya, in central Israel, and Hatzor, in the southern area.  

The Israel Rescue Services said there were no injuries or major damage reported throughout most of Israel.

The Magen David Adom medical aid group, however, said at least two people were being treated in northern Israel over shrapnel wounds.

The Jewish state’s counterattack hit nearly 300 targets allegedly tied to Hezbollah, with the bombings killing at least 9 people leaving another 48 injured, according to Lebanon’s Ministry of Health. 

The attacks come after a massive, two-day bombing campaign in Lebanon that killed more than 560 people, including Hezbollah’s top missile commander. 

The attacks are the deadliest strikes against Lebanon nearly two decades, prompting the Jewish state to issue mass evacuation notices to residents in southern Lebanon. 

Tens of thousands have already fled southern Lebanon and northern Israel amid the nearly year-long missile exchange, with Israeli Prime Minister Benjamin Netanyahu facing mounting pressure from displaced residents to end the conflict. 

Israeli officials have suggested a cease-fire could be reached so long as Hezbollah agrees to stop firing first. 

Hezbollah has said it would continue to attack in solidarity with Hamas, with the terror group vowing revenge over the mass pager and walkie-talkie detonations that killed nearly 40 people and wounded more than 3,000 others last week. 

With Post wires.